The mystery of life on the planet Mars continues to attract the attention of scientists and space enthusiasts. NASA, as one of the leading space research institutions, has made much progress in understanding the potential for life on Mars through specially designed missions. In recent years, recent discoveries have given new hope and deepened existing mysteries. One of the most interesting aspects is the presence of water on Mars. Research shows that there are signs of liquid water, which is key to supporting life. Recent discoveries by the Mars Reconnaissance Orbiter (MRO) mission indicate the existence of briny streaks, salt flows that may flow across the surface as temperatures rise. Liquid water opens up the possibility of microbial life in the past or even today. The Mars 2020 mission carried out by the Perseverance Rover also provides a clearer picture of the potential for life. This rover is equipped with sophisticated instruments capable of analyzing soil and rock samples. One of Perseverance’s main goals is to look for signs of old biology, which could be evidence that microorganisms once existed on the red planet. In addition, the presence of methane detected in the Martian atmosphere further strengthens speculation about life. Methane can be an indicator of life, as this gas is often produced by biological processes. The Curiosity Rover also conducted in-depth research at Gale Crater, where it discovered minerals containing traces of water. This discovery shows that the area once had an environment friendly to life. Additionally, research on the Pleistocene and Holocene of Mars has shown that climate change on Mars could have created conditions that supported living things, such as microbes. On the other hand, studies of the Martian atmosphere also provide new insights. The discovery of certain gases, such as nitrous oxide and argon, sparked debate among scientists about the possibility of biological activity. Sensitive measurements by measuring instruments on the rover provide in-depth data about the composition of the Martian atmosphere, allowing researchers to develop models of potential life. Research in astrobiology is also advancing. Understanding the extreme conditions that can support life on Earth has provided new insights for scientists in exploring the potential for life on Mars. Extremophile organisms on Earth, which are able to survive in extreme conditions, suggest that the possibility of life on Mars is not impossible. NASA also plans to return samples from Mars to Earth via the planned Mars Sample Return mission. This would be a significant achievement in astrobiology research and help confirm the existence of life on Mars. The technology used in this mission will encourage further developments in space research. The combination of scientific discoveries and technological advances raises hopes that we will one day find concrete evidence of life on Mars. With every mission launched and every sample analyzed, we get closer to solving the mystery of life on our neighboring planet. These missions are not just about exploring space, but also about understanding our origins and humanity’s place in this vast universe.